Diferencia entre la vacuna contra la influenza Forma trivalente y la forma tetravalente

: 24 de junio de 2022

La vacunación es el procedimiento para inmunizar a una persona contra infecciones y enfermedades que pueden ser fatales. La vacunación se basa en la administración de un antígeno, ya sea destruido por el calor o atenuado vivo, para generar una poderosa reacción inmune secundaria en el futuro.

Los mecanismos de las vacunas son bastante similares, sin embargo, hay dosis de influenza que difieren de un punto de estudio científico y de composición. Entonces, este artículo lo ayudará a dilucidar y comprender las diferencias estándar entre las formas trivalentes y tetravalentes de una vacuna contra la influenza.

Formulario trivalente de vacuna contra la influenza versus formulario tetravalente

La principal diferencia entre la vacuna contra la influenza trivalente y la forma tetravalente es que la forma trivalente protege contra tres cepas distintas del virus de la influenza, a saber; virus de la influenza A ( H3N2 ), virus de influenza A ( H1N1 ), y una cepa del virus de influenza B y la forma de uso está muerta e inactivada. Mientras que la forma tetravalente proporciona protección contra cuatro cepas del virus de la influenza; H3N2, virus de la influenza A ( H1N1 ), y dos cepas del virus B.

Una vacuna contra la gripe sintética compuesta por tres virus de influenza debilitados o muertos, de dos cepas distintas de influenza tipo A, así como una cepa de influenza tipo B, se conoce como vacuna trivalente contra la influenza o vacuna trivalente contra la influenza. Cada año, se desarrolla un plan trivalente de vacunación contra la influenza basado en virus de influenza que se espera que sean comunes durante la temporada de influenza y gripe. Esta sustancia puede producirse para inyección o uso nasal.

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La vacuna contra la influenza cuadrivalente

La vacuna contra la influenza cuadrivalente ( influenza ) es otro nombre para la vacunación contra la influenza tetravalente. Está hecho para protegerse contra cuatro virus de la gripe distintos, que comprenden dos cepas de virus de la influenza A y B. En los Estados Unidos, la mayoría de las vacunas contra la gripe para el año 2021-2022 son cuadrivales debido a la evolución de los virus de la influenza. La vacunación para diferentes edades ha sido autorizada. Una vacuna contra la gripe cuadrivalente está disponible para niños de hasta seis meses de edad. Flucelvax Quadrivalent ahora tiene licencia para su uso en niños de 2 años o más.

Tabla de comparación entre la forma trivalente de la vacuna contra la influenza y la forma tetravalente

Parámetros de comparación Forma trivalente <TAG de cuatro virus de la gripe distintos, que comprenden dos cepas de virus de la influenza A y B. Respuesta de anticuerpos Menos que la forma tetravalente de la vacuna contra la influenza. Más que la forma trivalente. Estado del anticuerpo La concentración de cepa de influenza diminuta en la vacuna es mortal o inactiva. La concentración de cepa de influenza diminuta en la vacuna es viva y atenuada. Población objetivo 6 meses de edad o más que eso.2 años o más. Dosis Ruta de dosificación de refuerzo intramuscular. Ruta intranasal.

¿Qué es la forma trivalente de la vacuna contra la influenza?

La influenza es una enfermedad altamente peligrosa que afecta predominantemente a una población alta cada año desde finales de otoño hasta principios de primavera, lo que hace que las personas afectadas pierdan el trabajo y la escuela, y en ciertos casos, ser hospitalizado. El uso de vacunas contra el virus de la influenza es la forma más corta e inteligente de lidiar con la enfermedad, sin embargo, hay 2 tipos de vacunas contra la gripe: trivalente y cuadrivalente, y esta parte del artículo hablará sobre la forma trivalente.

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La forma trivalente protege contra 3 variedades de virus de la gripe: virus de la influenza A ( H3N2 ), virus de la influenza A ( H1N1 ), así como el virus de la influenza B ( H1N1. El uso de la forma trivalente de la vacuna contra la influenza es más común que la forma tetravalente debido al efecto concentrado y la producción en masa de esta vacuna hizo que fuera más fácil y simple diversamente aplíquelo en una población más grande sin percances.

La vacunación trivalente contra la influenza todavía se sugiere cada año para todas las personas de 6 meses en adelante. En los EE. UU., Todas las vacunas contra la influenza hoy en día son cuadrivales; sin embargo, la forma trivalente todavía se usa ampliamente en países en desarrollo y del tercer mundo. Los nuevos componentes de vacunación contra el virus de la influenza A ( H3N2 ) e influenza A ( H1N1 ) se han agregado a las preparaciones para 2021 – 22.

¿Qué es la vacuna contra la influenza Tetravalente?

La vacuna contra la influenza tetravalente es otra vacuna sintética con acción inmunizante preventiva compuesta de antígenos de proteína de membrana ( HA ) generados a partir de cuatro cepas de gripe inactiva, dos cepas distintas de influenza A, y 2 cepas distintas de influenza tipo B.

Cada año, se forma una vacuna contra la influenza cuadrivalente ( QIV ) en función de las enfermedades virales que se espera sean comunes durante la próxima temporada de gripe. El QIV ofrece inmunización activa contra las cuatro cepas del virus de la gripe después de la inyección, evitando enfermedades de la influenza.

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Influenza Se han utilizado vacunas tetravalentes para proteger contra cuatro cepas diferentes de influenza ( comúnmente conocidas como gripe ). La vacunación funciona induciendo las defensas naturales del cuerpo ( anticuerpos ) hacia 4 cepas distintas de virus de influenza. Anualmente, surgen nuevas variedades de virus de influenza, y la tetravalencia se actualiza para incluir piezas de estos nuevos virus. Como resultado, se recomienda la vacunación contra la influenza cada año.

La vacuna contra la gripe tetravalente genera respuestas humorales contra las hemaglutininas y se elabora de la misma manera que las vacunas trivalentes contra la influenza; aunque el tetravalente cubre un rango de cepa más amplio, el mecanismo en general es el mismo.

Diferencias principales entre la forma trivalente de la vacuna contra la influenza y la forma tetravalente

  1. La vacuna trivalente no tiene un virus de influenza viva, mientras que la vacuna tetravalente tiene un virus vivo atenuado.
  2. La forma trivalente tiene resistencia al virus de 3 cepas, mientras que la forma tetravalente tiene resistencia al virus de 4 cepas.
  3. La forma trivalente es aplicable a humanos de 6 meses de edad o mayores, pero tetravalente es aplicable a cualquier persona mayor de 2 años.
  4. La forma trivalente es menos efectiva en comparación con la forma tetravalente abigarrada.
  5. La forma trivalente de influenza no tiene posibilidades de influenza aguda, mientras que la dosis tetravalente puede causar fiebre leve de influenza cuando se toma por primera vez.

Síntesis

Ambas categorías están designadas después de los tipos de influenza para los cuales proporcionan resistencia. La forma trivalente protege contra tres aislados del virus de la gripe: influenza A viral ( H3N2 ), virus de la gripe A ( H1N1 ), y el virus de la influenza B ( H1N1 ) y la forma tetravalente protege contra una cepa adicional del virus de la influenza B además de las protegidas por la variante trivalente de la vacuna contra la influenza. La forma trivalente es una vacuna inactivada, mientras que la forma tetravalente es un antígeno vivo.

  1. https://www.cdc.gov/flu/prevent/flushot.htm#:~:text=Influenza%20(flu)%20vaccines%20(often,a%20nasal%20spray%20flu%20vaccine.
  2. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/trivalent-influenza-vaccine
  3. https://clinicaltrials.gov/ct2/show/NCT01232868

Contenido

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